Some scientists warn that antibody testing is still a work in progress
CNN reports that some of the nation's top scientists briefed White House officials about antibody testing during a phone call last week and during the call, warned officials that antibody testing is still a work in progress.
Before delving into the specifics of the issues scientists are facing as they study antibody tests, it helps to understand exactly what these tests are and why they're considered vital in thwarting the spread of COVID-19.
Why antibody tests are considered vital in the fight against COVID-19
Antibody tests check to see if a person has previously been infected with Covid-19, an indication that they've had the virus and now could be immune to it.
This is why Dr. Deborah Birx, the coordinator of the White House coronavirus task force, has called such tests "critical."
The test can help determine if someone is immune to coronavirus, "and that's going to be important when you think about getting people back into the workplace," according to Dr. Anthony Fauci, a member of the task force.
"The antibody test says you were infected and if you're feeling well, you've very likely recovered," Fauci said. "As we look forward, as we get to the point of at least considering opening up the country as it were, it's very important to appreciate and to understand how much that virus has penetrated society."
Issues with current antibody tests
But on the April 6 phone call, members of the National Academy of Sciences' Standing Committee on Emerging Infectious Diseases and 21st Century Health Threats told members of the White House Office of Science and Technology Policy there are issues with the availability and reliability of the antibody tests in the United States right now.
"In three words: Work in progress," said Dr. David Relman, a member of the National Academy of Sciences committee who was on the call.
There are several layers of issues with the antibody tests.
First, the US Food and Drug Administration relaxed its rules, and now companies can sell antibody tests without submitting validation data that shows they actually work.
The American Public Health Lab Association says this has resulted in "crappy" tests flooding the market.
American Health Lab Association CEO Scott Becker said that during a Tuesday conference call, FDA Commissioner Dr. Stephen Hahn explained that antibody tests would undergo scientific review by the National Cancer Institute.
There has been concerns that some of the tests might confuse the coronavirus causing the current pandemic with one of several other coronaviruses that cause the common cold.
"Lots of tests confuse the two," Relman said.
The tests would then end up telling people they had antibodies associated with the pandemic coronavirus when they didn't, and people might think they're immune when they are not.
A few days after the phone call, the NAS scientists wrote a letter to the White House frankly apprising them about the quality of antibody tests.
Results from antibody tests "should be viewed as suspect until rigorous controls are performed and performance characteristics described, as antibody detection methods can vary considerably, and most so far have not described well-standardized controls," according to the letter.
Second, there are good tests in the midst of the bad ones, but they're not yet widely and easily available throughout the country.
Third, it's not entirely clear that having antibodies to Covid-19 means that you truly have immunity and won't get the disease again.
"That's the $64 question," said Dr. Harvey Fineberg, chairman of the NAS committee, who was also on the phone call with the White House. "Does antibody level equate to resistance to getting ill again?"
Fineberg added that antibody tests are important on a national scale, to gauge what proportion of the population might be immune, but also on a personal level.
"Everybody wants to know -- am I immune? Can I now visit Grandma so that I'm not a threat to her and she's not a threat to me?" he said. "How do we discern the people who can now safely go out and about? That's an important personal and social question."
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