(AP) — The U.S. and Israel launched a major attack on Iran on Saturday, and U.S. President Donald Trump called on the Iranian public to “seize control of your destiny” by rising up against the Islamic leadership that has ruled the nation since 1979.

Iranian Foreign Minister Abbas Araghchi told NBC News that Iran’s Supreme Leader Ayatollah Ali Khamenei and President Masoud Pezeshkian were alive “as far as I know.”

But hours later, Israeli Prime Minister Benjamin Netanyahu contradicted this in a nationally televised address: “There are growing signs that the tyrant is no longer alive,” he said.

The strikes opened a stunning new chapter in U.S. intervention in Iran and marked the second time in eight months that the Trump administration has used military force against the Islamic Republic.