WBRZ - Baton Rouge

The New Orleans Saints are going from a prime-time season opener to kick off the NFL season to a second straight game in the national spotlight.

Quarterback Drew Brees doesn't mind all the early season hype surrounding the defending Super Bowl champions.

They've had plenty of time to prepare for tonight's matchup at San Francisco following their Sept. 9 win over the Minnesota Vikings, a rematch of last season's NFC championship game.

Running back Reggie Bush makes his first appearance for the Saints since giving back the 2005 Heisman Trophy he won while with University of Southern California.

The NCAA punished USC after concluding that Bush and his family took money and gifts from sports agents while Bush played for the Trojans.

Bush says his energy is focused on the 49ers.